Numerous news outlets have reported on the thriving longevity industry, which is projected to be worth around $610 billion globally by 2025. Moreover, news stories are covering how the number of people living to 100 is growing and will continue doing so for the foreseeable future. Furthermore, it seems like more and more headlines are popping up about how to extend lifespan and what people, including celebrities, are doing to promote their longevity.

Altogether, these stories point to a new trend where people are focusing more on optimizing their longevity. Moreover, Harvard professor Dr. David Sinclair’s book, Lifespan—Why We Age and Why We Don’t Have to, has reached a wide audience, propelling many to jump on the bandwagon of trying to extend the number of years lived in a healthy state (a concept known as healthspan).

To address healthspan-related goals, Seragon has released a nutraceutical called Restorin, which contains a repertoire of components aimed at the underlying biological dysfunction that contributes to aging. Interestingly, Restorin is based on patents and licensed technologies from Harvard University, Mayo Clinic, and Scripps Research. These aging interventions were also improved upon by aging experts in Seragon’s R&D department. Since these top-tier institutions have developed the most recognized aging interventions in the world, combining their licensed technologies with Seragon’s R&D expertise holds promise to combat aging with Restorin.

Digging Deeper Into Restorin’s Technologies

Seragon’s aging intervention, known as SRN-901, which Restorin is roughly based on, contains components that inhibit a protein complex called mTOR. mTOR is involved in regulating cell growth and proliferation, and inhibiting it is thought to reduce inflammation, among other effects.

Another way to suppress mTOR comes from restricting dietary calories, which is the best way known to extend lifespan in preclinical studies with mice and monkeys. Moreover, another mTOR inhibitor that mimics the effects of calorie restriction called rapamycin, which is trending as a drug to potentially slow aging, has been shown to extend the lifespan of mice. By using mTOR inhibition that mimics calorie restriction, those who use Restorin may be able to reap the cellular benefits of restricting calories without having to alter their diets.

Restorin also contains components that stimulate autophagy — cellular processes where old and damaged cell parts are recycled and disposed of. Through autophagy stimulation, technologies contained in Restorin remove and recycle old proteins and structures in cells to make space for newer, more functional ones. In this way, autophagy may boost cellular function.

Moreover, Restorin contains components that have been shown to boost mitophagy — a cellular process that removes damaged mitochondria to improve overall mitochondrial quality — in Alzheimer’s models. Mitochondria are the energy-generating structures in cells, and their reduced operating capacities have been linked to age-related conditions. Through potentially stimulating mitophagy, components within Restorin may help stave off age-related physiological decline.

The product also contains senolytics — technologies that selectively eliminate dysfunctional cells that accumulate and may contribute to systemic inflammation as we age called senescent cells. Reducing the burden of senescent cells with senolytics has been proposed to alleviate signs of aging and has been shown to extend lifespan in preclinical studies with mice.

Restorin’s components are also designed to target the nicotinamide adenine dinucleotide (NAD+) pathway. NAD+ research has gained some degree of notoriety through Dr. Sinclair’s research, especially his study showing that increased levels of NAD+ improve male metabolic health and extend female lifespan in mice.

The Multiple Hallmarks of Aging

Aging researchers are targeting multiple hallmarks of aging that can be addressed to potentially slow our pace of age-related physical deterioration. Restorin’s repertoire of technologies addresses multiple hallmarks of aging, like disabled autophagy, mitochondrial dysfunction, cellular senescence, and inflammation.

Restorin’s Potential to Address Facets of Aging

The data showing the efficacy of Restorin and SRN-901 may confer some hope that this product addresses aspects of aging. All the same, it will be interesting to see whether those who take Restorin show improvements in metabolism, heart health, and cognitive function. In that sense, only future human trials will confirm whether any of the accounts of taking Restorin enhance physical and cognitive parameters to delay the processes of aging.